Pleckstrin homology domain-containing family D member 1 (PLEKHD1)

Pleckstrin homology domain-containing family D member 1 (PLEKHD1) is a protein-coding gene located on chromosome 14q24.1, encoding a protein characterized by a pleckstrin homology (PH) domain and coiled-coil region. PH domains typically bind phosphoinositides, suggesting potential involvement in intracellular signaling or membrane association, and coiled-coil domains are known for mediating protein-protein interactions. There is no current classification as a therapeutic target, receptor, or enzyme, and the biological function of PLEKHD1 remains poorly characterized, though some data suggest possible roles in cellular organization processes. No known drugs, biomarkers, or safety concerns are associated with this gene, and its disease relevance is limited, with only sparse mention of association to Aleutian mink disease.

Other names

Pleckstrin homology and coiled-coil domain containing D1PH domain-containing family D member 1UPF0639Pleckstrin homology domain containing, family D (with M protein repeats) member 1Pleckstrin homology domain containing, family D (with coiled-coil domains) member 1

null (no drug mechanisms of action defined for this molecule)