Pleckstrin homology domain-containing family F member 2 (PLEKHF2)

Pleckstrin homology domain-containing family F member 2 (PLEKHF2) is a cytosolic protein predicted to bind phosphatidylinositols via its pleckstrin homology (PH) and FYVE domains, directing it to specific membrane compartments such as endosomes. It is likely involved in early endosome fusion upstream of the small GTPase RAB5, thereby regulating receptor trafficking and fluid-phase transport. PLEKHF2 may also enhance cellular sensitivity to tumor necrosis factor (TNF)-induced apoptosis, suggesting a role in cell death processes. While structurally related to other PH/FYVE superfamily members, it has no current evidence of being a direct drug target or therapeutic receptor. The gene product is a phosphoinositide-binding protein involved in endosomal membrane trafficking and apoptosis. The protein is encoded by the PLEKHF2 gene (HGNC: 20757) and has no established clinical role as a biomarker or approved drug target. No known small molecule drugs or therapeutic antibodies interact with PLEKHF2 as of current sources, nor is it classified as a traditional receptor, enzyme, ion channel, or transporter. Its major function is predicted, not fully characterized experimentally, primarily inferred from bioinformatics and limited functional studies in cellular models.

Other names

ZFYVE18PHAFIN2Phafin2EAPFEndoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domainsPleckstrin homology and FYVE domain containing 2Pleckstrin homology domain-containing family F member 2PH and FYVE domain-containing protein 2Zinc finger FYVE domain-containing protein 18FLJ13187