Pleckstrin homology domain-containing family J member 1 (PLEKHJ1)

Pleckstrin homology domain-containing family J member 1 (PLEKHJ1) is a protein-coding gene found in humans and other species, encoding a protein that contains a pleckstrin homology domain[1][2]. This protein is predicted to participate in cellular processes such as endosome organization, receptor recycling, and retrograde transport from endosomes to the Golgi apparatus[2][3]. It is primarily localized to cellular compartments such as the Golgi apparatus, cytosol, cytoplasmic vesicles, early endosome, and recycling endosome[2][3]. PLEKHJ1 has been described in fusion events with TCF3 in cancer genome data, although its independent role in disease or as a therapeutic target is not well established[5]. There are no known drugs or biomarkers clinically validated for this gene, and no established safety concerns associated with it.

Other names

pleckstrin homology domain containing J1guanine nucleotide releasing protein xGNRPXPH domain-containing family J member 1pleckstrin homology domain-containing family J member 1FLJ102979530063M10Rik