Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Pleckstrin homology domain-containing family M member 3 (PLEKHM3)
- Target
- PLEKHM3
- Molecular classification
- Other (Scaffold protein containing a pleckstrin homology domain)
01
Overview
Pleckstrin homology domain-containing family M member 3 (PLEKHM3) is a protein encoded by the PLEKHM3 gene, predicted to act as a scaffold protein during skeletal muscle differentiation, potentially mediating AKT1 activity in this process. It is also predicted to bind metal ions such as zinc and is typically localized to the Golgi apparatus. Pathogenic mutations in the gene have been associated with median neuropathy and chondroid chordoma.
- Other names
- DAPRDifferentiation associated proteinPLEKHM1LPH domain-containing family M member 3Pleckstrin homology domain containing, family M, member 3Pleckstrin homology domain containing, family M, member 1-like
02
Biological functions
Skeletal muscle differentiationPotential scaffold for AKT1 during muscle differentiationMetal ion bindingZinc ion binding
03
Disease associations
Median neuropathyChondroid chordoma
Beyond the preview
Go deeper on Pleckstrin homology domain-containing family M member 3 (PLEKHM3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Pleckstrin homology domain-containing family M member 3 (PLEKHM3).