Pleckstrin homology-like domain family B member 1 (PHLDB1)

Pleckstrin homology-like domain family B member 1 (PHLDB1) is a cytoplasmic protein highly expressed in brain and adipose tissue, with a critical role in insulin signaling. It contains a C-terminal pleckstrin homology (PH) domain that binds phosphoinositides (notably PI(3,4)P₂ and PI(3,4,5)P₃), and an N-terminal forkhead-associated (FHA) domain that binds phosphorylated threonine and tyrosine residues. Upon insulin stimulation, PHLDB1 translocates to the plasma membrane where it enhances Akt phosphorylation, leading to increased GLUT4 translocation and glucose uptake in adipocytes. Genetic polymorphisms near PHLDB1 are associated with glioma risk, and its modulation of the Akt pathway may contribute to metabolic changes observed in certain cancers. PHLDB1 functions predominantly as a scaffold/adaptor protein and is not a classic therapeutic target. It is also involved in regulating cytoskeletal dynamics and adhesion at the basal cortex of cells.

Other names

KIAA0638LL5ADLNB07FLJ00141LL5aLL5alphaOI23Protein LL5-alpha

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