Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Pleckstrin homology-like domain family B member 2 (PHLDB2)
- Target
- PHLDB2
- Molecular classification
- Other: cytoskeletal-associated protein, Pleckstrin homology domain-containing protein
01
Overview
Pleckstrin homology-like domain family B member 2 is a multi-domain cytoplasmic protein characterized by two coiled-coil domains and a pleckstrin homology (PH) domain. It functions as a key adaptor that links the cell cortex to microtubules by anchoring microtubule plus-ends at the plasma membrane through PI(3,4,5)P₃ binding. This anchoring promotes microtubule stability, regulates focal adhesion disassembly, and facilitates directed cell migration and polarity. In neurons, PHLDB2 is pivotal for dendritic spine maturation and synaptic plasticity via interaction with drebrin A. It also organizes cytoskeletal platforms for cell motility, interacting with components such as CLASPs, ERC1a, liprin-α1, Amotl2, and FLNC. While not currently considered a direct therapeutic target, altered expression is correlated with prognosis in several breast cancer subtypes, making it a candidate biomarker for disease progression.
- Other names
- PHLDB2LL5βLL5BFLJ21791LL5bProtein LL5-beta
02
Mechanism of action
Not applicable (no drugs directly target PHLDB2)
03
Biological functions
Microtubule anchoring to the cell cortexRegulation of dendritic spine morphology and synaptic plasticity via actin cytoskeletonFocal adhesion turnover and cell migrationBasement membrane organizationCadherin bindingRegulation of wound healing and spreading of epidermal cellsPostsynaptic apparatus assembly (possible role in acetylcholine receptor aggregation)
04
Disease associations
Cancer (expression linked to prognosis in breast cancer, especially HER2+ and triple-negative subtypes)May be associated with congenital fibrosis of extraocular muscles and Three M syndrome 1 (genetic association, limited direct mechanistic data)
05
Biomarkers
May act as a prognostic or predictive marker in certain breast cancer subtypes (e.g., HER2+, triple-negative, luminal A/B)
Beyond the preview
Go deeper on Pleckstrin homology-like domain family B member 2 (PHLDB2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Pleckstrin homology-like domain family B member 2 (PHLDB2).