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Pleckstrin homology MyTH4 and FERM domain-containing protein H3 (PLEKHH3)
- Target
- PLEKHH3
- Molecular classification
- Other (multi-domain scaffold/adaptor protein)
01
Overview
Pleckstrin homology MyTH4 and FERM domain-containing protein H3 (PLEKHH3) is a human protein encoded by the PLEKHH3 gene. It contains multiple protein interaction domains, including pleckstrin homology (PH), MyTH4, and FERM domains, which are commonly involved in cytoskeletal linkage and membrane association, suggesting an adaptor or scaffold protein function. PLEKHH3 has been reported to localize in the extracellular space, but its precise biological roles are largely uncharacterized. Limited evidence links PLEKHH3 to certain cancers, such as tracheal tumors, but it is not currently considered a therapeutic target or established biomarker[3][5].
- Other names
- Pleckstrin homology domain-containing family H member 3PH domain-containing family H member 3FLJ21019pleckstrin homology domain containing family H (with MyTH4 domain) member 3
02
Biological functions
Other (function not well characterized, but related to protein-protein and membrane interactions due to the presence of PH, MyTH4, and FERM domains)
03
Disease associations
Cancer (reported association with trachea adenoid cystic carcinoma and tracheal cancer[3])
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