Plectin 1 pseudogene

This entry refers to a **pseudogene** related to the functional *Plectin 1* gene (PLEC), described as "pseudogene similar to part of plectin 1, intermediate filament binding protein 500kDa." A pseudogene is a segment of DNA that resembles a known gene but has lost its gene expression or protein-coding ability due to disabling mutations such as frameshifts or premature stop codons[2][4]. Pseudogenes are non-functional and do not produce functional protein; they may be annotated due to sequence similarity but lack the biological activity of the parent gene[4]. In this case, ENSG00000251373 does not encode the functional protein plectin 1, which is a large cytoskeletal linker protein essential for maintaining cell and tissue integrity[1][3][7]. There is no evidence that the pseudogene has therapeutic, biological, or disease relevance, nor is it a receptor, enzyme, or target for drugs. The entry is most likely irrelevant for therapeutic targeting and may be annotated in databases due to sequence homology or as a computational artifact[4][6].

Other names

Plectin 1, intermediate filament binding protein 500kDa pseudogeneENSG00000251373PLEC1 pseudogene