Plexin-A2 receptor (PLXNA2)

Plexin-A2 receptor (PLXNA2) is a single-pass transmembrane protein and a member of the plexin-A family, which acts as a co-receptor for specific semaphorins (notably SEMA3A, SEMA6A/B, and SEMA3C) and mediates axon repulsion and guidance during nervous system development[1][2][6]. By transducing semaphorin signals—often with neuropilin co-receptors—Plexin-A2 triggers cytoskeletal remodeling, directing neuron migration and networking. It plays critical roles in central nervous system development, cell migration, and, importantly, has been shown to promote cell proliferation and tumor growth (notably in glioblastoma)[3][7][8]. Mutations or abnormal expression of PLXNA2 are implicated in various neurological and developmental disorders, including intellectual disability, schizophrenia, and certain congenital anomalies[1][2]. High expression correlates with poor prognosis in some cancers, suggesting therapeutic relevance and potential as an anti-tumorigenic target[3].

Other names

Plexin-A2PLXNA2KIAA0463OCTPLXN2UNQ209/PRO235FLJ11751FLJ30634Semaphorin receptor OCTplexin 2transmembrane protein OCT

Modulation of semaphorin interaction and downstream signaling; Regulation of cell proliferation pathways (e.g., via FARP2, FYN, AKT, and p38MAPK)