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Target intelligence / Profile preview
Plexin-A4 (PLXNA4)
- Target
- PLXNA4
- Molecular classification
- Receptor, Semaphorin receptor, Membrane protein
01
Overview
Plexin-A4 is a single-pass transmembrane receptor primarily involved in semaphorin signaling, where it acts as a coreceptor for neuropilin and class 3 semaphorins such as Sema3A, Sema6A, and Sema6B[1][2][3]. It is abundantly expressed in the nervous system and mediates processes including axonal guidance, synaptic targeting, neural differentiation, and neural regeneration. Plexin-A4 signaling leads to cytoskeletal reorganization, affecting cell migration, axon pruning, dendritic branching, and vascular remodeling[1][3][4][7]. Plexin-A4 is also implicated in immune regulation and has been found to play a role in the pathogenesis of Alzheimer’s disease, partly through its interaction with clusterin (CLU)[5], and may serve as a therapeutic target in cancer and neurodegenerative diseases.
- Other names
- Plexin-A4PLXNA4KIAA1550PLXNA4APLXNA4BUNQ2820/PRO34003DKFZp434G0625FAYV2820PLEXA4PRO34003epididymis secretory sperm binding protein
02
Mechanism of action
Modulation of semaphorin signaling pathways; Regulation of cytoskeletal rearrangement via actin and microtubule destabilization; Alteration of cell migration, angiogenesis, and immune responses through signal transduction
03
Biological functions
Signal transductionAxon guidanceRegulation of cell migrationCytoskeletal remodelingNeural developmentVascular remodelingImmune response
04
Disease associations
Neurodegenerative disease (e.g., Alzheimer’s disease)Cancer (including glioblastoma and tumor progression)Vascular diseasePotential roles in inflammation and immune modulation
05
Safety considerations
Targeting may alter neural function, given key roles in nervous system development and maintenancePotential for effects on learning, memory, or neural regeneration pathways[5]Possible off-target effects in vascular or immune cells
06
Interacting drugs
None directly approved; experimental interactions with B7-H4 fusion protein (immune modulation) are reported[3]
07
Biomarkers
PLXNA4 expression (potential biomarker for Alzheimer’s disease risk[5]; possible marker in neural injury and certain cancers[4])
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