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Target intelligence / Profile preview
Plexin-B1 (PLXNB1)
- Target
- PLXNB1
- Molecular classification
- Receptor, Type I transmembrane glycoprotein
01
Overview
Plexin-B1 is a transmembrane receptor protein belonging to the plexin family that plays crucial roles in various biological processes including neuronal guidance, cell migration, angiogenesis, and immune response. It serves as a high-affinity receptor for Semaphorin 4D (SEMA4D/CD100) and is implicated in several pathological conditions including cancer, idiopathic hypogonadotropic hypogonadism, preeclampsia, and intracerebral hemorrhage.
- Other names
- CD100 antigenPLXNBCD100
02
Mechanism of action
Plexin-B1 signaling involves receptor dimerization, Rho GTPase binding, R-Ras GAP activity, receptor complex formation, and activation of the PI3K/Akt pathway. Therapeutic interventions could target these mechanisms to modulate Plexin-B1 function in disease.
03
Biological functions
Transmembrane signalingNeuronal guidanceCell migration controlGTPase regulationAngiogenesisImmune regulation
04
Disease associations
Cancer progressionIdiopathic hypogonadotropic hypogonadismPreeclampsiaIntracerebral hemorrhage
05
Safety considerations
Modulating Plexin-B1 signaling could have unintended effects on neuronal development, angiogenesis, or immune function.
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