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Target intelligence / Profile preview
Plexin-B2 (PLXNB2)
- Target
- PLXNB2
- Molecular classification
- Type I transmembrane glycoprotein, Receptor
01
Overview
Plexin-B2 (PLXNB2) is a type I transmembrane glycoprotein that functions as a cell surface receptor primarily for class 4 semaphorins and angiogenin (ANG). It plays critical roles in cell-cell signaling, axon guidance, cell migration, and cytoskeletal reorganization. PLXNB2 is involved in various cellular processes, including brain development, angiogenesis, and immune responses, making it a potential therapeutic target for cancer, neurodegenerative diseases, and hematopoietic disorders. Targeting the ANG-PLXNB2 axis has shown promise in preclinical studies.
- Other names
- DJ402G11.3KIAA0315MM1Nbla00445PLEXB2
02
Mechanism of action
The mechanism of action for drugs targeting PLXNB2 typically involves blocking the binding of its ligands (e.g., SEMA4C, Angiogenin) or disrupting its downstream signaling pathways (e.g., RHOA, AKT/ERK).
03
Biological functions
Cell signalingAxon guidanceNeuronal migrationCell migrationCytoskeletal reorganizationAngiogenesis regulationERBB2 phosphorylationRho GTPase regulation
04
Disease associations
CancerNeurodegenerative diseasesHematopoietic disordersDevelopmental disorders
05
Safety considerations
Potential for off-target effects due to broad expression.Disruption of normal developmental processes.Complex signaling pathways may lead to unpredictable outcomes.
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