Plexin domain-containing protein 2 (PLXDC2)

Plexin domain-containing protein 2 (PLXDC2) is a multifunctional cell-surface receptor that mediates diverse signaling pathways. Originally identified as a receptor for pigment epithelium-derived factor (PEDF), it facilitates PEDF-induced neurotrophic and antiangiogenic responses. PLXDC2 is expressed in various tissues, including the eye, where its genetic variants are associated with susceptibility to primary open-angle glaucoma. In cancer, particularly head and neck squamous cell carcinoma, PLXDC2 is upregulated and drives tumor cell plasticity, epithelial-mesenchymal transition, and cancer stem cell enrichment, contributing to radioresistance and tumor aggressiveness; silencing this receptor can restore radiotherapy sensitivity. It is predicted to localize to the cell membrane, and is implicated in tumor angiogenesis and vascular regulation, positioning it as a potential, though still emerging, therapeutic target[1][4][5][6].

Other names

Plexin domain containing 2Tumor endothelial marker 3TEM7RPLXDC2

Not applicable (no clinically established drugs); experimental studies suggest modulation through antagonism or silencing may suppress cancer cell plasticity and restore radiotherapy sensitivity[1]