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Target intelligence / Profile preview
PML-RARA regulated adaptor molecule 1 (PRAM1)
- Target
- PRAM1
- Molecular classification
- Other (Adaptor protein), Signaling scaffold protein
01
Overview
PML-RARA regulated adaptor molecule 1 (PRAM1) is a cytoplasmic adaptor protein implicated in signal transduction during immune cell (especially neutrophil and T cell) activation and differentiation. Its expression is regulated during normal myelopoiesis and is induced by retinoic acid, but suppressed by the oncogenic fusion PML-RARα in acute promyelocytic leukemia. Functionally, PRAM1 is similar to the FYN binding protein FYB/SLAP-130, participates in integrin signaling in neutrophils, and helps coordinate integrin-dependent cell responses such as adhesion and reactive oxygen species (ROS) production. Loss of PRAM1 impairs neutrophil degranulation and integrin-mediated signaling. It has also been implicated in the retinoic acid-induced differentiation program suppressed in leukemogenesis, and interacts with signaling proteins like HIP-55 and TRIM27[1][2][3].
- Other names
- PML-RARPRAM-1PRAMPML-RARA-regulated adapter molecule 1PML-RARA target gene encoding an Adaptor Molecule-1
02
Biological functions
Signal transductionImmune response modulation (involvement in T cell receptor and integrin-mediated neutrophil signaling)Regulation of myeloid differentiation
03
Disease associations
Cancer (especially acute promyelocytic leukemia, APL)Other (potential roles in hematologic malignancies)
04
Biomarkers
Potential biomarker for differentiation status in myeloid/hematopoietic cells or pathway activity in APL (indirectly, as its expression is regulated by retinoic acid and PML-RARα fusion protein)
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