Target intelligence / Profile preview

Pneumococcal histidine triad protein D (PhtD)

Target: PhtD
Molecular classification: Polyhistidine Triad Proteins, Surface Protein

Overview

Pneumococcal histidine triad protein D is an essential surface antigen involved primarily in zinc uptake and immune evasion mechanisms of S. pneumoniae. Its strong conservation across strains and ability to induce broad protective immunity make it an attractive target for next-generation universal pneumococcal vaccines.

Other names: PhtDStreptococcus pneumoniae histidine triad protein D

Mechanism of action

Antibodies against PhtD facilitate pneumococcal clearance through complement- and macrophage-dependent opsonophagocytosis.

Biological functions

Zinc homeostasisMetal Ion HomeostasisImmune evasion via complement inhibitionAdhesionComplement inhibition

Disease associations

InfectionPneumoniaSepsis

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