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Target intelligence / Profile preview
PNMA family member 3 (PNMA3)
- Target
- PNMA3
- Molecular classification
- Other (Paraneoplastic antigen), Cancer-testis antigen, Retroviral Gag-like protein family
01
Overview
PNMA family member 3 (PNMA3), also known as paraneoplastic antigen Ma3 or MA3, is a protein-coding gene in the PNMA family, which shows homology to retroviral Gag proteins. PNMA3 is highly expressed in the brain and in various tumors frequently associated with paraneoplastic neurological syndromes, where autoantibodies to this antigen are markers of disease. Alternative splicing creates several isoforms, but the protein's precise role in normal physiology and disease remains largely uncharacterized. It is not currently established as a direct therapeutic target, but its immunogenicity and brain/tumor expression pattern make it notable for cancer-associated neurological autoimmunity[1][3][6].
- Other names
- Paraneoplastic antigen Ma3MA3MA5MGC132756MGC132758Paraneoplastic cancer-testis-brain antigen
02
Mechanism of action
None applicable
03
Biological functions
Expression in brain and paraneoplastic tumorsPutative role in neuronal function due to brain expressionNucleic acid binding (based on limited Gene Ontology annotation)
04
Disease associations
Cancer (notably paraneoplastic neurological syndromes)Neurodegenerative disease (paraneoplastic syndromes with neurological phenotypes)Potential links with Alzheimer disease (association only)
05
Safety considerations
None directly associated with therapeutic targeting
06
Interacting drugs
None reported
07
Biomarkers
Paraneoplastic syndrome antibody marker
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