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Target intelligence / Profile preview
POC1 centriolar protein A (POC1A)
- Target
- POC1A
- Molecular classification
- Other (centrosomal protein), WD40 repeat protein
01
Overview
POC1 centriolar protein A (POC1A) is a centrosomal protein characterized by an N-terminal WD40 domain and a C-terminal coiled-coil domain[3][4][6]. It is essential for the assembly, stability, and function of centrioles and the formation of cilia. POC1A participates in the early steps of centriole duplication as well as in regulating centriole length, thus ensuring proper cell division and maintaining genomic stability. Mutations in POC1A lead to short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) syndrome[3][4][1]. In cancer biology, especially gastric cancer, POC1A acts as a tumor suppressor, regulating the cell cycle, DNA replication, and likely contributing to immune infiltration within the tumor microenvironment[1]. Its decreased expression is associated with tumor progression and poorer outcomes, making it a potential prognostic biomarker in oncology[1]. There are currently no known drugs directly targeting POC1A.
- Other names
- POC1 centriolar protein homolog AWDR51ADKFZP434C245Pix2Proteome of centriole protein 1AWD repeat-containing protein 51APIX2SOFTWD repeat domain 51A
02
Biological functions
Centriole assembly and stabilityCiliogenesis (cilia formation)Cell cycle regulationDNA replicationChromosome segregationMitotic spindle formation
03
Disease associations
Cancer (notably gastric cancer as tumor suppressor)Genetic disorders (e.g., short stature, onychodysplasia, facial dysmorphism, and hypotrichosis—SOFT syndrome)
04
Safety considerations
Genetic mutations result in SOFT syndrome and other developmental disorders
05
Biomarkers
Prognostic marker for gastric cancerPotential biomarker for immune infiltration and lymph node metastasis in gastric cancer
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