Podocalyxin-like protein 2 (PODXL2)

Podocalyxin-like protein 2 (PODXL2) is a cell surface transmembrane protein and a member of the CD34 family, characterized by an N-terminal mucin domain, single-pass membrane region, and charged cytoplasmic tail[1][2][5]. It acts as a high-affinity ligand for vascular selectins, mediating the rapid rolling of leukocytes over vascular endothelium by interacting with E-, P-, and L-selectins in a cation-dependent manner[1][2][3][5]. Its primary biological role appears to be in immune cell trafficking and inflammation, with additional associations documented in rare diseases such as Moebius syndrome[2]. There is currently no evidence for direct therapeutic targeting with drugs or established biomarker status. Key features of this target: - Canonical name and abbreviation are standardized and in line with primary scientific databases. - PODXL2 functions as a ligand, not traditionally characterized as a classical receptor or enzyme, but it plays a critical role in immune surveillance and response through selectin binding[1][2][3][5]. - No interacting drugs or direct therapeutic mechanisms identified in available sources.

Other names

PODXL2EGPODLX2Endoglycanpodocalyxin like 2endoglycanUNQ1861/PRO3742