Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Podocan-like protein 1 (PODNL1)
- Target
- PODNL1
- Molecular classification
- Other (Extracellular matrix structural constituent, small leucine-rich repeat protein family)
01
Overview
Podocan-like protein 1 (PODNL1) is a member of the small leucine-rich repeat protein (SLRP) family, functioning as an extracellular matrix structural constituent, particularly active in collagen-containing matrices[1][2][5]. PODNL1 has drawn research attention as its methylation status in tumor tissue has been shown to correlate with immune cell infiltration, immune checkpoint molecule expression (such as PD-L1, PD-1, CTLA4), and outcomes in lower-grade glioma, making it a proposed biomarker for prognosis and immunotherapy response[1][4]. There is currently no evidence that PODNL1 functions as a receptor, enzyme, transporter, or established therapeutic target, and there are no drugs known to act directly on it[1][2][5].
- Other names
- Podocan-like 1SLRR5BFLJ23447
02
Biological functions
Extracellular matrix organizationCollagen bindingStructural constituent of matrix
03
Disease associations
Cancer (notably lower-grade glioma; involved as a biomarker)Other (possibly implicated in tissue remodeling, but strong disease roles are limited to biomarker evidence in cancer)
04
Biomarkers
PODNL1 methylation status (prognostic biomarker for lower-grade glioma)
Beyond the preview
Go deeper on Podocan-like protein 1 (PODNL1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Podocan-like protein 1 (PODNL1).