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Podoplanin (PDPN)

Target: PDPN
Molecular classification: Transmembrane glycoprotein

Overview

Podoplanin (PDPN) is an O-glycosylated transmembrane protein involved broadly across developmental biology, immunology—especially leukocyte trafficking—and oncology due to its regulatory effects on cellular adhesion/motility signaling pathways. Its main known physiological ligand is CLEC‑2.

Other names: E11 antigengp38T1arTI40PA2.26OTS-8AggrusPlatelet aggregating factor

Mechanism of action

Unknown

Biological functions

Cell motilityCell adhesionOrgan developmentLymphatic vessel developmentDendritic cell migrationImmune cell traffickingMacrophage polarization

Disease associations

CancerOral premalignancyLymphangiomaAngiosarcoma

Safety considerations

Promotes tumorigenesis and metastasis

Biomarkers

Follicular dendritic cell tumorsAngiosarcomaOral premalignancy lesions

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