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Target intelligence / Profile preview
Pol polyprotein
- Molecular classification
- Enzyme, Polyprotein
01
Overview
The Pol polyprotein is a large, multifunctional precursor protein encoded by retroviruses, including HIV-1 and foamy viruses. It is essential for viral replication and maturation. It contains the enzymatic machinery required for Protease (PR), Reverse Transcriptase (RT), and Integrase (IN). Processing of the Pol polyprotein by the viral protease is crucial for generating functional viral enzymes.
02
Mechanism of action
Inhibition of protease, reverse transcriptase, or integrase activity
03
Biological functions
Viral replicationReverse transcriptionIntegration of viral DNAProteolytic processing of viral proteins
04
Disease associations
Infection
05
Safety considerations
Drug resistanceOff-target effects of inhibitors
06
Interacting drugs
Protease inhibitors
2 more in the full profile.
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