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Target intelligence / Profile preview
Human Immunodeficiency Virus Type 1 Pol Polyprotein (HIV-1 Pol)
- Target
- HIV-1 Pol
- Molecular classification
- Enzyme, Polyprotein
01
Overview
The Human Immunodeficiency Virus type 1 (HIV-1) Pol polyprotein is a large precursor protein encoded by the *pol* gene of HIV-1. It contains the viral enzymes protease (PR), reverse transcriptase (RT), and integrase (IN), which are essential for viral replication. The Pol polyprotein is produced as part of a longer Gag-Pol polyprotein through ribosomal frameshifting. After translation, the Gag-Pol polyprotein is cleaved by the viral protease into its functional components. These enzymes are major targets for antiretroviral drugs.
- Other names
- HIV-1 Pol polyproteinPol polyproteinGag-Pol polyprotein (precursor)
02
Mechanism of action
Inhibition of protease, reverse transcriptase, or integrase activity, preventing viral replication and maturation.
03
Biological functions
Viral protein processing/maturationReverse transcription of RNA genomeIntegration into host cell DNA
04
Disease associations
InfectionHIV/AIDS
05
Safety considerations
Drug resistanceSide effects of antiretroviral drugsViral rebound upon treatment interruption
06
Interacting drugs
Protease inhibitors
2 more in the full profile.
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