POLE4 pseudogene 1 (POLE4P1)

POLE4 pseudogene 1 (POLE4P1) is a **pseudogene** related by sequence to the functional gene *POLE4* (DNA polymerase epsilon 4, accessory subunit)[6]. Pseudogenes like POLE4P1 generally do not encode functional proteins and are not considered therapeutic targets, receptors, enzymes, or transporters[4][6]. While some pseudogenes can regulate their parental genes at the RNA level (for example, via competitive endogenous RNA activity), there is no specific evidence that POLE4P1 has such a function or disease association[4][6]. The functional *POLE4* gene product is a histone-fold protein involved in DNA replication and repair as part of DNA polymerase epsilon[1][5], but this does not apply to the pseudogene. **Context and supporting details:** - *POLE4* is a well-characterized DNA-binding protein and part of the DNA polymerase epsilon complex, but POLE4P1 is designated as a pseudogene and lacks protein-coding ability[6]. - Pseudogenes may sometimes influence gene regulation in cancer and other diseases[4], but there is no published evidence that POLE4P1 plays such a role. - No drugs, mechanisms of action, biomarkers, or notable safety concerns are reported for POLE4P1, as it is not a therapeutic target[6]. **Entry issues:** - Although POLE4P1 is a real pseudogene record[6], it is **not an active molecular target** for therapeutic or diagnostic development. - Searches for POLE4P1 return only that it is a pseudogene and do not identify any biological function, disease association, or role as a protein or RNA target. This target entry is considered "incorrect" for a therapeutic context as it refers to a pseudogene, not a protein or functional RNA target.

Other names

POLE4P1POLE4 pseudogene 1