Poliovirus Antigen (Inactivated) (IPV Antigen)

The inactivated poliovirus antigen is the immunogenic component of the inactivated polio vaccine (IPV). It comprises whole poliovirus particles, typically inactivated by formaldehyde, retaining their ability to induce a protective immune response. The antigen is derived from one or more of the three poliovirus serotypes (types 1, 2, and 3). The inactivation process can modify or destroy certain epitopes, especially those at site 1 on types 2 and 3, leading to reduced binding by some monoclonal antibodies. IPV induces a strong humoral immune response characterized by production of neutralizing antibodies. Immunogenicity can vary depending on whether wild-type or attenuated Sabin strains are used.

Other names

Inactivated PoliovirusIPV antigenSalk Vaccine Antigen

Induction of neutralizing antibodies against poliovirus serotypes 1, 2, and 3.