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Target intelligence / Profile preview
Poliovirus Capsid Protein (N/A)
- Target
- N/A
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The poliovirus capsid is the protein shell that encases the viral RNA genome. It is a highly structured, icosahedral assembly composed of four distinct viral proteins: VP1, VP2, VP3, and VP4. The capsid mediates attachment to the host cell receptor CD155/PVR, facilitates entry and uncoating, and protects the viral genome. VP1 interacts directly with the host receptor CD155/PVR. VP4 is located on the inner face of the capsid and is released during uncoating to facilitate genome release into host cells. Assembly proceeds via pentameric intermediates containing immature forms like myristoyl-VP0 before final cleavage yields mature virions.
- Other names
- VP1VP2VP3VP4P1 capsid precursor
02
Mechanism of action
N/A
03
Biological functions
Viral attachmentViral entryViral uncoatingVirion assemblyGenome protection
04
Disease associations
InfectionPoliomyelitis
05
Safety considerations
Potential for viral resistanceImmune evasion
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