Target intelligence / Profile preview

Poliovirus Capsid Protein VP1 (None)

Target: None
Molecular classification: Viral structural protein, Capsid protein

Overview

Poliovirus capsid protein VP1 is one of the four structural proteins (VP1, VP2, VP3, and VP4) that make up the icosahedral shell of the poliovirus virion. Each virion contains 60 copies of each capsid protein. VP1 interacts directly with CD155 (also known as PVR or poliovirus receptor), mediating attachment to host epithelial cells. Upon binding to CD155, poliovirus undergoes a conformational change to form a cell entry intermediate. Antibodies against VP1 can neutralize infectivity.

Mechanism of action

N/A

Biological functions

Receptor bindingCell entryViral capsid formation

Disease associations

Infection

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