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Target intelligence / Profile preview
Poliovirus Receptor (PVR)
- Target
- PVR
- Molecular classification
- Immunoglobulin superfamily, Nectin family, Type I transmembrane glycoprotein, Receptor
01
Overview
The Poliovirus Receptor (PVR), also known as CD155, is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It functions in cell adhesion, immune regulation, viral entry (specifically for poliovirus), and tumor biology. It interacts with immune receptors such as CD226 (DNAM-1) and TIGIT, modulating NK and T cell activity. PVR expression is upregulated in various cancers, making it a potential biomarker and therapeutic target. Engineered polioviruses are being investigated as cancer therapies due to their tropism for high-PVR-expressing cancer cells.
- Other names
- CD155Nectin-like protein 5NECL-5
02
Mechanism of action
Engineered polioviruses targeting tumors; antibodies modulating its function
03
Biological functions
Cell adhesionCell migrationImmune regulationViral entryLeukocyte transmigrationSignal transduction
04
Disease associations
Poliovirus infectionCancerInflammation
05
Safety considerations
Immunoevasion through fratricide or transfer mechanisms in tumor overexpression
06
Biomarkers
Differential expression across cancers
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