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Target intelligence / Profile preview
Poliovirus receptor related immunoglobulin domain containing protein (PVRIG)
- Target
- PVRIG
- Molecular classification
- Poliovirus Receptor-Like Proteins, Receptor, Type I transmembrane protein, Immune checkpoint receptor
01
Overview
PVRIG (Poliovirus receptor related immunoglobulin domain containing protein), also known as CD112R, is an immune checkpoint receptor expressed on T cells and NK cells. It binds to Nectin-2 (CD112/PVRL2) on antigen-presenting cells and tumor cells, delivering inhibitory signals that suppress T cell and NK cell activation and cytotoxicity. As such, PVRIG is a therapeutic target in cancer immunotherapy to enhance anti-tumor immunity.
- Other names
- CD112R
02
Mechanism of action
PVRIG antibodies block the PVRIG/Nectin-2 interaction, preventing inhibitory signaling and enhancing T cell and NK cell activity.
03
Biological functions
Immune responseRegulation of T cell activityRegulation of NK cell activityT-cell receptor signaling inhibition
04
Disease associations
CancerImmune evasion
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