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Poliovirus serotype 1

Molecular classification: Virus, Enterovirus, Picornaviridae, Enterovirus C

Overview

Poliovirus serotype 1 (PV-1) is one of three serotypes of poliovirus responsible for poliomyelitis. It is a non-enveloped virus with a single-stranded, positive-sense RNA genome. PV-1 enters cells via the CD155 receptor and replicates in the oropharynx/gut before potentially invading the central nervous system, leading to paralysis. While wild-type PV-1 is now endemic in only a few countries, vaccine-derived strains can still circulate. Vaccines are available using inactivated or live attenuated virus.

Other names: PV-1Poliovirus type 1

Mechanism of action

Vaccines induce humoral immunity against the virus, preventing infection and subsequent disease.

Biological functions

Viral replicationInfectionHost cell entry

Disease associations

PoliomyelitisParalysisViral infection

Safety considerations

Vaccine-derived poliovirus (VDPV) can emerge from live attenuated vaccines in areas with low immunization coverage.Risk of paralysis associated with wild-type infection.

Interacting drugs

Inactivated poliovirus vaccine

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