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Target intelligence / Profile preview
Poliovirus Type 1 Capsid Protein (Sabin Strain)
- Molecular classification
- Structural Protein, Viral Capsid Protein
01
Overview
The poliovirus type 1 capsid protein (Sabin strain) is a structural protein component of the attenuated type 1 poliovirus used in the oral polio vaccine (OPV). The Sabin strains are live, weakened forms of wild-type polioviruses, developed to induce immunity without causing disease. The capsid proteins form the outer shell of the virus particle and are critical for its infectivity, antigenicity, and interaction with host cell receptors. It is not a therapeutic target, it is a viral protein.
02
Mechanism of action
The oral poliovirus vaccine (OPV) utilizes the Sabin strain to induce an immune response against the poliovirus. The capsid protein elicits antibody production, neutralizing the virus and preventing infection.
03
Biological functions
Encapsulation of viral RNA genomeHost cell attachment via CD155/PVRViral entryAntigen presentation
04
Disease associations
PoliomyelitisVaccine-associated paralytic poliomyelitis (VAPP)
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Safety considerations
Reversion to virulenceVaccine-associated paralytic poliomyelitis (VAPP)
06
Interacting drugs
Poliovirus vaccine (oral)
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