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Poliovirus Type 2 Antigen (Inactivated)

Molecular classification: Vaccine, Inactivated Viral Vaccine, Poliovirus Vaccine, Antigen

Overview

Poliovirus type 2 antigen (inactivated) is a purified, formaldehyde-inactivated preparation of poliovirus type 2, typically derived from the MEF-1 strain. It is used as a component of inactivated poliovirus vaccines (IPV) for active immunization against poliomyelitis caused by poliovirus type 2. The antigen is produced by growing the virus in continuous lines of monkey kidney cells and then inactivating it with formaldehyde. Upon administration, it stimulates the immune system to produce neutralizing antibodies specific to poliovirus type 2 without causing disease, leading to reduced pharyngeal excretion and transmission potential upon exposure to live virus while providing individual protection from paralytic polio disease caused by serotype 2 infection.

Other names: Poliovirus Type 2 Antigen (Formaldehyde Inactivated)Inactivated Type 2 Poliovirus (MEF-1)Poliovirus vaccine inactivated, type 2 (MEF-1)Inactivated poliomyelitis vaccine type 2 MEF1Formaldehyde-inactivated PV Type 2Inactive PV Type II MEF-1

Mechanism of action

Induces neutralizing antibody response via D-antigens

Biological functions

Antigen presentationImmune response inductionAntibody productionActive immunizationInduction of humoral immunity

Disease associations

PoliomyelitisViral Infection

Safety considerations

Potential allergic reactionsRare adverse events associated with vaccine administration

Interacting drugs

Ipol

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