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Poliovirus type 2 MEF‑1 strain capsid proteins (PV2 MEF-1 capsid)

Target: PV2 MEF-1 capsid
Molecular classification: Viral structural protein, Capsid protein

Overview

The capsid proteins of the poliovirus type 2 MEF-1 strain (VP1, VP2, VP3, VP4, and VP0) form the outer protein shell that protects the viral RNA genome. These proteins are essential for viral infectivity, host cell interaction, and antigenicity. The MEF-1 strain is a laboratory reference strain used in vaccine development and research. It is also used as an antigen standard in diagnostic assays. High-resolution structures are available, aiding in the development of capsid-binding antiviral compounds.

Other names: Poliovirus 2 MEF-1 capsid proteinsMEF-1 capsidPoliovirus type 2 MEF-1 VP1Poliovirus type 2 MEF-1 VP2Poliovirus type 2 MEF-1 VP3Poliovirus type 2 MEF-1 VP4Poliovirus type 2 MEF-1 VP0

Mechanism of action

Capsid binders inhibit viral uncoating or assembly; IPV elicits neutralizing antibodies against the capsid.

Biological functions

Viral genome encapsulationHost cell receptor bindingAntigen presentationViral entry

Disease associations

PoliomyelitisParalytic disease

Safety considerations

Potential for accidental release and outbreaksRisk associated with live attenuated vaccine strainsBiosafety protocols required for handling

Interacting drugs

Capsid binder compounds (unspecified)

1 more in the full profile.

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