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Target intelligence / Profile preview
Poliovirus Type 3 Capsid Protein (Inactivated) (PV3 Capsid (Inactivated))
- Target
- PV3 Capsid (Inactivated)
- Molecular classification
- Viral structural protein, Capsid protein, Antigen
01
Overview
The poliovirus type 3 capsid protein, when inactivated, refers to the structural proteins forming the outer shell of the type 3 poliovirus that has been rendered non-infectious—typically by formalin treatment—for use in vaccines such as the inactivated polio vaccine (IPV). The most commonly used strain for IPV is Saukett/USA/50. The capsid proteins (VP1, VP2, VP3, VP4) protect the viral RNA and elicit an immune response after vaccination. Inactivation is achieved by formalin treatment, which preserves key epitopes while preventing infectivity.
- Other names
- Inactivated Poliovirus Type 3PV3 Capsid Protein (Inactivated)Saukett/USA/50 strain capsid protein (inactivated)Inactivated Poliovirus Type 3 Antigen
02
Mechanism of action
Formalin inactivation prevents viral replication and infectivity while preserving antigenicity for immune response.
03
Biological functions
Viral capsid formationHost cell attachment (prior to inactivation)Antigen presentationImmune response induction
04
Disease associations
Poliomyelitis (prevention)Viral infection (Poliovirus Type 3)
05
Safety considerations
Potential for incomplete inactivationRisk of allergic reaction to vaccine components
06
Interacting drugs
Formalin (inactivation agent)
1 more in the full profile.
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