Target intelligence / Profile preview

Poliovirus types 1, 2, and 3 antigens (PV-Ag-(types I/II/III))

Target: PV-Ag-(types I/II/III)
Molecular classification: Viral structural protein, Capsid protein, Antigen

Overview

Poliovirus types 1, 2, and 3 antigens are the structural proteins, primarily capsid proteins VP1, VP2, VP3, and VP4, that elicit an immune response. These antigens are crucial for serotype-specific recognition by neutralizing antibodies and are the basis for both live attenuated (OPV) and inactivated (IPV) polio vaccines. Detection of antibodies against these antigens is used to assess immunity to each serotype.

Other names: Polio capsid protein antigensEnterovirus C antigensPoliovirus type 1 antigenPoliovirus type 2 antigenPoliovirus type 3 antigen

Mechanism of action

OPV: Live attenuated virus stimulates immune response; IPV: Inactivated virus stimulates immune response without causing infection.

Biological functions

Viral entryImmune recognitionAntibody neutralizationVaccine developmentDiagnostic testing

Disease associations

PoliomyelitisParalysisViral infection

Safety considerations

Vaccine-derived poliovirus (VDPV) in OPVSerotype-specific immunityAntigenic drift

Interacting drugs

Oral Polio Vaccine (OPV)

2 more in the full profile.

Biomarkers

Neutralizing antibody titers

Beyond the preview

Go deeper on Poliovirus types 1, 2, and 3 antigens (PV-Ag-(types I/II/III)).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Poliovirus types 1, 2, and 3 antigens (PV-Ag-(types I/II/III)).

Explore the full profile