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Target intelligence / Profile preview
Poliovirus types 1-3 (inactivated)
- Molecular classification
- Virus, Picornaviridae, Enterovirus, Enterovirus C
01
Overview
Inactivated poliovirus types 1, 2, and 3 are non-infectious forms of the poliovirus used in vaccines to induce immunity against poliomyelitis. These viruses, belonging to the *Picornaviridae* family, *Enterovirus* genus, and *Enterovirus C* species, are chemically treated (typically with formaldehyde) to eliminate their ability to replicate while preserving their antigenic structure. Vaccination with inactivated poliovirus stimulates the production of neutralizing antibodies that prevent viral attachment and entry into host cells, thereby providing protection against paralytic disease. The three serotypes are included due to the lack of cross-protection between them.
- Other names
- Inactivated PoliovirusIPVPoliovirus serotype 1 (inactivated)Poliovirus serotype 2 (inactivated)Poliovirus serotype 3 (inactivated)Mahoney strain (inactivated)MEF-1/Lansing strain (inactivated)Saukett/Leon strain (inactivated)
02
Mechanism of action
Induction of neutralizing antibodies that block virus-receptor interaction (CD155/PVR) and prevent viral entry into host cells.
03
Biological functions
Viral infectionAntigen presentationImmune response inductionAntibody production
04
Disease associations
PoliomyelitisViral infection
05
Safety considerations
Potential for inadequate inactivation (extremely rare with current manufacturing processes)Allergic reactions to vaccine components
06
Interacting drugs
Formaldehyde (used for inactivation)
1 more in the full profile.
07
Biomarkers
Neutralizing antibody titers against poliovirus serotypes 1, 2, and 3
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