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Poliovirus Types 1-3 Antigens
- Molecular classification
- Viral Capsid Protein, Antigen
01
Overview
Poliovirus types 1, 2, and 3 are the three serotypes of poliovirus, each defined by distinct capsid proteins (VP1, VP2, VP3, and VP4) that determine their antigenic properties. These antigens are critical for immune recognition and vaccine development. The major antigenic sites are Site 1 (VP1 aa89–100), Site 2a/b (VPs 220–222/169–170), and Site 3. The three types do not cross-protect, necessitating trivalent vaccines. Neutralizing antibody titers against these antigens indicate immunity.
- Other names
- Poliovirus Type 1 AntigenPoliovirus Type 2 AntigenPoliovirus Type 3 AntigenPV1 AntigenPV2 AntigenPV3 AntigenVP1 (Poliovirus)VP2 (Poliovirus)VP3 (Poliovirus)VP4 (Poliovirus)
02
Mechanism of action
Vaccines induce neutralizing antibodies against the viral capsid proteins, preventing viral entry and infection.
03
Biological functions
Viral entryImmune recognitionAntibody neutralizationVaccine-induced immunity
04
Disease associations
PoliomyelitisParalysisInfection
05
Safety considerations
OPV can revert to virulent forms in rare cases, causing vaccine-derived poliovirus (VDPV)IPV requires booster shots to maintain long-term immunity.
06
Interacting drugs
Inactivated Poliovirus Vaccine (IPV)
1 more in the full profile.
07
Biomarkers
Neutralizing antibody titers against poliovirus types 1, 2, and 3
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