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Target intelligence / Profile preview
Poliovirus Types 1-3 Capsid Proteins (Inactivated) (IPV Capsid Proteins)
- Target
- IPV Capsid Proteins
- Molecular classification
- Viral structural protein, Capsid protein, Antigen
01
Overview
Inactivated poliovirus vaccine (IPV) contains purified capsid proteins from poliovirus types 1, 2, and 3. These proteins, primarily VP1, VP2, VP3, and VP4, are rendered non-infectious by formaldehyde treatment. They retain their antigenic structure, stimulating the production of neutralizing antibodies specific for each serotype, thus providing immunity against poliomyelitis without the risk of disease. The main function of these capsid proteins in the vaccine is to induce a protective immune response.
- Other names
- Inactivated Poliovirus Vaccine AntigensPV-1 Capsid Proteins (Mahoney strain)PV-2 Capsid Proteins (MEF-I strain)PV-3 Capsid Proteins (Saukett strain)Poliovirus VP1Poliovirus VP2Poliovirus VP3Poliovirus VP4
02
Mechanism of action
Formalin inactivation cross-links amino groups on the viral capsid proteins, preserving antigenic sites while abolishing infectivity, leading to the production of neutralizing antibodies.
03
Biological functions
Viral capsid formationHost cell receptor bindingInduction of neutralizing antibodiesImmune response stimulation
04
Disease associations
PoliomyelitisViral infection
05
Safety considerations
Rare allergic reactions to vaccine componentsManufacturing process control for complete inactivation
06
Interacting drugs
Formaldehyde (inactivation agent)
2 more in the full profile.
07
Biomarkers
Neutralizing antibody titers against PV-1Neutralizing antibody titers against PV-2Neutralizing antibody titers against PV-3
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