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Poliovirus types I–III antigens
- Molecular classification
- Viral capsid protein, Antigen
01
Overview
Poliovirus types I–III antigens are the antigenic components of the three serotypes of poliovirus (PV-1, PV-2, and PV-3). These antigens, primarily located on the viral capsid proteins VP1, VP2, and VP3, are critical for inducing neutralizing antibodies and providing protective immunity against poliomyelitis. They are the targets of both inactivated (IPV) and live-attenuated (OPV) polio vaccines. The presence of D-antigen is essential for vaccine potency. Key antigenic sites include Site I, Site II, and Site III, with varying immunodominance across the three serotypes. Diagnostic assays detect these antigens for quantification and characterization of poliovirus.
- Other names
- PV-1 antigensPV-2 antigensPV-3 antigensPoliovirus type 1 antigensPoliovirus type 2 antigensPoliovirus type 3 antigensD-antigen (Poliovirus)C-antigen (Poliovirus)
02
Mechanism of action
Vaccine-induced antibody neutralization of poliovirus.
03
Biological functions
Immune recognitionAntibody bindingViral neutralizationInduction of protective immunity
04
Disease associations
PoliomyelitisInfection
05
Safety considerations
Vaccine-derived poliovirus (VDPV) in OPVRare cases of vaccine-associated paralytic poliomyelitis (VAPP) in OPV
06
Interacting drugs
Oral Polio Vaccine (OPV)
1 more in the full profile.
07
Biomarkers
Antibody titers against PV-1Antibody titers against PV-2Antibody titers against PV-3D-antigen levels
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