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Target intelligence / Profile preview
Poliovirus Types I and III (PV-1 & PV-3)
- Target
- PV-1 & PV-3
- Molecular classification
- Virus, RNA virus, Picornaviridae, Enterovirus
01
Overview
Poliovirus Types I and III are two of the three serotypes of poliovirus, a causative agent of poliomyelitis. They are distinguished by differences in their capsid proteins, affecting their antigenicity and receptor specificity. Eradication efforts target these serotypes using vaccines like OPV and IPV.
- Other names
- Poliovirus Type 1PV1Poliovirus Type 3PV3
02
Mechanism of action
Vaccine-induced antibody neutralization of the virus, preventing infection of host cells.
03
Biological functions
Viral replicationHost cell infectionImmune evasionNeuroinvasion
04
Disease associations
PoliomyelitisParalysisPost-polio syndrome
05
Safety considerations
Vaccine-derived poliovirus (VDPV) emergence with OPVRare cases of vaccine-associated paralytic poliomyelitis (VAPP) with OPV
06
Interacting drugs
Oral Polio Vaccine (OPV)
1 more in the full profile.
07
Biomarkers
Antibody titers against PV-1 and PV-3Viral RNA detection in stool samples
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