Target intelligence / Profile preview

Pollen Allergen

Molecular classification: Protein, Glycoprotein

Overview

Pollen allergens are proteins or glycoproteins found within the pollen grains of various plants (trees, grasses, weeds). These molecules trigger allergic reactions in sensitized individuals upon inhalation, leading to allergic rhinitis, conjunctivitis, and asthma exacerbations. Specific IgE antibodies mediate the allergic response, causing mast cell degranulation and release of inflammatory mediators. Allergen immunotherapy aims to induce immune tolerance and reduce sensitivity over time.

Other names: Pollen allergensBet v 1Ragweed pollenGrass pollenTree pollen

Mechanism of action

Antihistamines: H1 receptor antagonism; Nasal corticosteroids: Reduction of inflammation; Allergen immunotherapy: Induction of immune tolerance

Biological functions

Plant reproduction (indirect)Immune response (allergy induction)

Disease associations

Allergic rhinitisAllergic conjunctivitisAsthma

Safety considerations

Anaphylaxis (immunotherapy)Side effects of antihistamines (drowsiness, dry mouth)Side effects of corticosteroids (nasal irritation, systemic effects with long-term use)

Interacting drugs

Antihistamines

2 more in the full profile.

Biomarkers

Specific IgE levelsSkin prick test reactivity

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