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Target intelligence / Profile preview
Pollen Allergen Bet v 1 (Bet v 1)
- Target
- Bet v 1
- Molecular classification
- Pathogenesis-related protein family PR-10, Allergen
01
Overview
Bet v 1 is the major allergen found in birch (Betula verrucosa) pollen, responsible for most cases of birch pollen allergy. It is a ~17 kDa protein belonging to the PR-10 family. Its structure features a hydrophobic cavity that binds various ligands, influencing its stability and immunogenicity. The iron-free form promotes Th2 lymphocyte responses, while the iron-bound form exhibits reduced Th2 skewing. Sensitization to Bet v 1 is a biomarker for birch pollen allergy, and immunotherapy targeting this allergen has shown efficacy.
- Other names
- Birch pollen allergen Bet v 1
02
Mechanism of action
Immunotherapy targeting Bet v 1 aims to desensitize patients, shifting the immune response away from Th2 dominance.
03
Biological functions
Ligand bindingPlant defense (homologous)Immune response modulation
04
Disease associations
Allergic rhinitisAsthmaBirch pollen allergy
05
Safety considerations
Potential for allergic reactions during immunotherapy.
06
Biomarkers
Sensitization to Bet v 1 predicts allergic rhinitis and asthma due to birch pollen exposure.
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