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Target intelligence / Profile preview
Serine/threonine-protein kinase PLK1 (PLK1)
- Target
- PLK1
- Molecular classification
- Enzyme, Serine/threonine kinase
01
Overview
Serine/threonine-protein kinase PLK1 (PLK1) is a key regulatory enzyme that plays essential roles in cell cycle progression, particularly during mitosis. It is a master regulator of multiple processes during cell division, including centrosome maturation, spindle assembly, kinetochore function, chromosome segregation, and cytokinesis. PLK1 is highly expressed in many cancers, making it an attractive target for anticancer therapy. Several inhibitors are under clinical investigation.
- Other names
- polo-like kinase 1STPK13serine/threonine-protein kinase 13
02
Mechanism of action
PLK1 inhibition
03
Biological functions
Cell cycleMitotic entryMitotic progressionSpindle formationChromosome segregationCytokinesisDNA damage response
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to kinase family similarityToxicity in normal proliferating cellsDrug resistance
06
Interacting drugs
Volasertib
1 more in the full profile.
07
Biomarkers
PLK1 expression levels
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