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Target intelligence / Profile preview
Polo-like kinase 2 (PLK2)
- Target
- PLK2
- Molecular classification
- Enzyme, Serine/threonine-protein kinase, Polo-like kinase family
01
Overview
Polo-like kinase 2 (PLK2) is a serine/threonine-protein kinase and a member of the polo-like kinase family, which plays critical roles in cell cycle regulation, cell division, and various cellular processes. It is involved in mitotic centriole replication, meiotic chromatin pairing, synapsis, and crossing-over, cell differentiation, ontogenesis, stress response, tumorigenesis, neurodegenerative diseases, inflammation, and injury responses. PLK2's dysregulation is linked to tumorigenesis and neurodegenerative diseases. Modulating PLK2 activity may hold therapeutic potential for cancer and neurodegenerative diseases.
02
Mechanism of action
Kinase inhibition (potential)
03
Biological functions
Cell cycle controlMitotic centriole replicationMeiosisCell differentiationOntogenesisStress responseAutophagy regulation
04
Disease associations
CancerNeurodegenerative diseaseHereditary breast ovarian cancer syndrome
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