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Target intelligence / Profile preview
Polo-like kinase family member PLK1 (PLK1)
- Target
- PLK1
- Molecular classification
- Enzyme, Serine/threonine kinase
01
Overview
PLK1 is a serine/threonine kinase that plays a crucial role in cell cycle progression, particularly during mitosis. It regulates various processes including mitotic entry, spindle assembly, chromosome segregation, and cytokinesis. PLK1 is frequently overexpressed in various cancers, promoting uncontrolled cell proliferation and chromosomal instability, making it a promising target for anticancer drug development.
- Other names
- Serine/threonine-protein kinase PLK1polo-like kinase 1 (PLK-1)Serine/threonine-protein kinase 13 (STPK13)
02
Mechanism of action
Inhibition of PLK1 catalytic activity leads to mitotic arrest and apoptosis.
03
Biological functions
Cell cycle regulationMitotic entrySpindle assemblyChromosome segregationDNA repairCheckpoint recoveryApoptosis regulationMetabolism controlRNA processingVesicle transport
04
Disease associations
Cancer
05
Safety considerations
Hematologic toxicity
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