Poloxamer 181

Poloxamer 181 is a synthetic, nonionic surfactant belonging to the poloxamer family, composed of a central hydrophobic polyoxypropylene chain flanked by two hydrophilic polyoxyethylene chains. It is commonly sold under the trade names Pluronic L-61 and Synperonic L61, and is used primarily as a solubilizing agent, emulsifier, and excipient in industrial, cosmetic, and pharmaceutical applications. Its key technological properties include temperature- and concentration-dependent micelle and gel formation, which can be useful for drug delivery purposes. While poloxamers including 181 have been evaluated for enhancing drug delivery and sensitizing drug-resistant cancers, they are not themselves therapeutic molecular targets, receptors, or enzymes.

Other names

Pluronic L-61Synperonic L61Spectrum Poloxamer 181

Functions by forming micelles that encapsulate hydrophobic drugs, thereby increasing their solubility, bioavailability, and delivery. Can sensitize resistant cancer cells, likely by modifying cellular uptake through membrane effects.