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Poloxamine 1107

Molecular classification: Synthetic polymer, Nonionic surfactant, Block copolymer

Overview

Poloxamine 1107 (also known as Tetronic 1107 or T1107) is a synthetic, nonionic block copolymer surfactant consisting of four arms of ethylene oxide (EO) and propylene oxide (PO) blocks attached to a central ethylenediamine core. Its typical molecular weight is approximately 15,000 Da, and it is highly amphiphilic—capable of interacting with hydrophobic and hydrophilic compounds—which makes it useful as an emulsifier, dispersant, and solubilizing agent in a wide range of formulations. In aqueous environments, Poloxamine 1107 can form micelles and temperature/pH-responsive gels, making it valuable for controlled drug delivery systems, enhancing the bioavailability of poorly-soluble drugs, and stabilizing pharmaceutical and cosmetic formulations. Poloxamine 1107 is not itself a therapeutic target, biomarker, or drug, but a versatile excipient that supports a broad range of industrial, pharmaceutical, and biomedical uses.

Other names: Tetronic 1107T1107Block Copolymer SurfactantNonionic SurfactantPoly(ethylene oxide)-Poly(propylene oxide) CopolymerEmulsifying AgentDispersant

Mechanism of action

Acts via physical encapsulation of hydrophobic drugs in micelles or gels, enhancing solubility and potentially modulating drug release profile.

Biological functions

Formulation excipientMicelle formationSolubilizationEmulsificationControlled drug release excipient

Safety considerations

Low toxicity in vitro (fibroblast viability >70%)Generally considered biocompatibleMay cause irritation if handled inappropriately as with many surfactantsSpecific drug formulation safety depends on overall formulation

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