Poly(ADP-ribose) polymerase family member 8 pseudogene

The poly(ADP-ribose) polymerase family member 8 pseudogene is a non-coding genomic sequence that resembles the functional PARP8 gene but contains mutations or disruptions that prevent it from encoding the active poly(ADP-ribose) polymerase family member 8 protein. Pseudogenes arise by duplication or retrotransposition of functional genes followed by the accumulation of disabling mutations. This specific pseudogene does not produce a functional enzyme and is not considered a therapeutic target, biomarker, or disease gene. While the functional parental gene PARP8 is involved in NAD+-dependent ADP-ribosylation of proteins and related to processes such as DNA repair (for the broader PARP family), the pseudogene does not participate in these pathways.