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Target intelligence / Profile preview
Poly(adenosine-diphosphate-ribose) polymerase 1 (PARP1)
- Target
- PARP1
- Molecular classification
- Enzyme, PARP family
01
Overview
Poly(adenosine-diphosphate-ribose) polymerase 1 (PARP1) is a multifunctional nuclear enzyme that plays a crucial role in maintaining genome integrity, responding to cellular stress, and regulating transcription. It is a key player in DNA damage repair, particularly in response to single-strand and double-strand breaks. PARP1's activity is essential for base excision repair, nucleotide excision repair, non-homologous end joining, and homologous recombination repair. Its inhibition is therapeutically exploited in cancers with defective homologous recombination pathways.
- Other names
- ADPRT1poly[ADP-ribose] polymerase 1
02
Mechanism of action
PARP inhibitors block PARP1 enzymatic activity, preventing DNA repair, leading to cell death in cells with homologous recombination deficiencies.
03
Biological functions
DNA Damage Sensing & RepairChromatin Remodeling & Transcription RegulationCell differentiationProliferationTumor transformationGenome integrity maintenanceCellular stress response
04
Disease associations
CancerInflammationFanconi anemiaType I diabetes
05
Safety considerations
Increased replication stressDamage responses
06
Interacting drugs
PARP inhibitors
07
Biomarkers
BRCA mutations
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