Poly(ADP-ribose) polymerase family member 10 (PARP10)

Poly(ADP-ribose) polymerase family member 10 (PARP10) is a human enzyme encoded by the PARP10 (ARTD10) gene and is part of the poly(ADP-ribose) polymerase family, a group of enzymes involved in DNA repair, genomic stability, and the regulation of chromatin structure and gene transcription[3][7]. Specifically, PARP10 functions as a mono-ADP-ribosyltransferase, mediating the transfer of a single ADP-ribose moiety to target proteins such as histones, thereby modulating transcriptional activity and chromatin organization[9]. While clinical therapeutics have focused on other PARPs (such as PARP1/2) in cancer, PARP10 is increasingly studied for its role in gene regulation and potential oncogenic pathways[4][7]. Several PARP inhibitors (e.g., veliparib, 3-aminobenzamide) have been used in structural and functional studies of PARP10, but selective inhibition and disease-specific targeting of PARP10 remains under investigation[4].

Other names

Poly [ADP-ribose] polymerase 10Mono-ADP-ribosyltransferase PARP10ADP-ribosyltransferase diphtheria toxin-like 10ARTD10

Inhibition of enzyme catalytic activity (by small molecule PARP inhibitors)[4]