Poly(ADP-ribose) polymerase family member 12 (PARP12)

Poly(ADP-ribose) polymerase family member 12 (PARP12) is an enzyme belonging to the PARP superfamily, characterized as a mono-ADP-ribosyltransferase. It contains CCCH-type zinc finger domains and WWE domains, enabling interactions with RNA and poly-ADP-ribose (PAR), and is involved in nuclear, cytoplasmic, and stress granule processes. PARP12 performs mono-ADP-ribosylation of target proteins, including RIPK1 and RIPK3, regulating cell death pathways such as necroptosis and apoptosis, particularly in response to TNFα and interferon signaling[4][5]. It also plays a role in antiviral defense, stress granule assembly, and the regulation of protein transport between the Golgi apparatus and plasma membrane[2][1]. In cancer (e.g., hepatocellular carcinoma), it impacts cancer cell migration and invasion by controlling the stability of proteins such as FHL2[1]. PARP12 is also highly expressed in brown adipose tissue, where it is implicated in mitochondrial function and thermogenesis[3]. There are no well-characterized drugs currently targeting PARP12, and it is considered a non-redundant modulator within the broader family of ADP-ribosyltransferases.

Other names

Protein mono-ADP-ribosyltransferase PARP12ZC3HDC1ARTD12PARP-12FLJ22693ZC3H1MST109MSTP109Zinc finger CCCH domain-containing protein 1ADP-ribosyltransferase diphtheria toxin-like 12

Mono-ADP-ribosylation of proteins affecting cell death pathways (e.g., MARylation of RIPK1, RIPK3); Modulation of protein stability and trafficking pathways; Regulation of stress granule dynamics under stress conditions