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Target intelligence / Profile preview
Poly-N-acetylglucosamine Polysaccharide (PNAG)
- Target
- PNAG
- Molecular classification
- Exopolysaccharide, Polysaccharide
01
Overview
Poly-N-acetylglucosamine polysaccharide (PNAG) is a structurally conserved exopolysaccharide critical to biofilm architecture across numerous pathogenic bacteria. Its unique chemical features enable strong adhesive properties essential for persistent infections on biotic and abiotic surfaces. Due to its ubiquity among pathogens and immunogenic potential, it remains an important focus for anti-biofilm therapeutic strategies including vaccines targeting device-related infections.
- Other names
- Polysaccharide Intercellular AdhesinPIAPS/A
02
Mechanism of action
Inhibition of bacterial adherence, disruption of biofilm formation, antibody-mediated neutralization
03
Biological functions
Biofilm formationSurface attachmentCell-cell interactionsImmune evasionAdhesion
04
Disease associations
InfectionDevice-associated infectionsChronic colonizationCystic fibrosis lung infections
05
Safety considerations
Potential for off-target effects if antibodies cross-react with host glycansDevelopment of resistance through altered PNAG structure or expression
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